I am interpreting "coolest" as "ones I haven't thought of yet," so am skipping some of the more normal ones and trying to think outside the box:
Beneficial:
Bacteria Whisperer - The human body contains far more bacteria cells than human cells ... and you have a subconscious, instinctive bond with the bacterial flora that populate your body. Because of this, certain biological systems are optimized, specifically:
1. Enhanced digestion - require 50% of the food of a normal human
2. Enhanced immunity - benefits to resisting disease and infection
3. Enhanced anti-toxicity - benefits to resisting poison
4. Self-awareness - because the entire body contains bacteria, the Bacteria Whisperer gains a Perception check to sense any unusual entity within their body, ranging from a microscopic tracking device to a miniscule tumor, or a physical change that they wouldn't normally be able to detect. A woman, for example, may well be able to use this ability to instantly sense if she has become pregnant.
Marsupial pouch - Natural storage pocket. Items hidden here raise the difficulty of a Search/Perception/Whatever check to find here.
Skunk attack/Putrescine discharge (controlled) - You discharge a foul-smelling toxin that debilitates anyone with functioning olfactory senses. Causes intense pain to those with acute olfactory senses.
http://en.wikipedia.org/wiki/PutrescineEmotionless - Your mind is not capable of feeling a specific emotion. Attempts to manipulate, deceive, or affect you in any way that calls upon that emotion automatically fail. However, your complete inexperience with that emotion earns you a penalty on any attempt to understand or deal with a situation where understanding of that emotional state would be helpful, such as calming an angry person or attempting to distract someone through seduction. (Another mutation could be "No Emotion," which cuts off all emotions, instead of just one.)
Detachable Hand - One of your hands is detachable. It may walk on its fingers or "stand" on its stump, and has full manual dexterity to perform tasks at your command. You receive full touch (and pain) sensory input from the hand and, if you cannot see, then you are able to use touch as needed (and possible) to interpret what it is examining. This mobile hand has a range of 200 feet, and you always instinctively know the direction and distance toward the hand (even if it's over 200 feet away). You gain a bonus to any touch-based perception check using this hand (even when it's still attached to you).
Detrimental:
Putrescine discharge (uncontrolled) - The discharge of putrescine is not under your control as an attack strategy. It means you are generally unwelcome in polite society ... and most impolite society, for that matter.
System 1 Mental Failure - Your mind does not automate certain cognitive processes. When you see a word in a language you know, it takes a conscious decision by your brain to read it. You must think about the answer to 2 + 2. The worst functional effect is that you are not unconsciously looking around at your surroundings. Without pre-declared conscious effort to watch for it, you do not get a perception check to detect a surprise.
Waddle - Your legs are fused together, so you essentially have one thick leg with two feet branching off it. You have an incredibly slow movement speed. This also looks awkward and can result in various social penalties as appropriate.
Slap Happy - Due to a neurochemical imbalance in the brain, you are continuously locked in a euphoric emotional state. You constantly smile and are prone to giggling uncontrollably. You gain the benefits and drawbacks of the "Emotionless: Anger" and "Emotionless: Fear" mutations. In addition, any attempt to be taken seriously by others suffers severe penalties.
Soft Bones/Brittle Bones - Soft Bones means that your bones are prone to bending. Attempts to assault others with brawl or melee weapons suffer a penalty, because your bones aren't hard enough to reinforce the blows. Brittle Bones means that your bones are prone to breaking. Attempts to harm you suffer a damage bonus and healing times from physical attacks are 20% longer. (Recovery from diseases, poison, and other forms of damage are normal.)